Moon face is a side effect of prednisone due to which mechanism?

• A. Redistribution of fat from limbs to face
• B. Increase in appetite
• C. Acne formation
• D. Hair loss

Answer: (A)

Moon face comes from the way excess glucocorticoids, like prednisone, change fat distribution in the body. These steroids mimic Cushingoid effects and cause fat to be deposited more in central areas (including the face) while peripheral fat in the limbs is reduced, and muscles in the arms and legs can waste away. That combination makes the face appear rounded and puffy—the characteristic moon face. Increased appetite and weight gain can accompany prednisone use, but the defining feature here is the redistribution of fat, not just extra calories. Acne or hair loss aren’t the primary drivers of this facial change.